Dermal uses of non-irritating retinoids

Details Dermal uses of non-irritating retinoids Dermal uses of non-irritating retinoids

A - Human Necessities

61

K

167/207, 167/255

A61K 31/215 (2006.01) A61K 8/67 (2006.01) A61K 31/33 (2006.01)

Patent

CA 2004861

-22- The dermal use of non-irritating retinoids such as the esters and amides of 13-cis and 13-trans-retinoic acid for effecting the reduction and reversal of photoaging and skin cancer is disclosed. The retinoids having the formulae: Image Image wherein R is Image , Image , Image , Image , Image , Image , Image , Image , Image , Image , Image , Image , Image , Image , and Image wherein X is -H, -F, -Cl, -Br, -I, -OH, -OR, -OR', Image , Image , Image , -CN, -NO2, -NH2, -NHR', or -NR'2; wherein n is a number from 1 to 5; wherein R' is H or any of the lower alkyls ranging from C1 to C6; wherein R" is Image , -OR', Image , or -R'; wherein each R~ is R' or the hydrocarbon backbone of fatty acids; and further, where there are two or more R', R", or R~ groups attached to the same carbon or nitrogen, each R', R", or R~ may be the same as or different from the other R', R", or R~ groups attached to that carbon or nitrogen,

Utilisation au niveau du derme de retinoïdes non irritants, comme les esters et les amides d'acides 13-cis et 13-trans-rétinoïques pour réduire et inverser le photovieillissement et le cancer de la peau. Les rétinoïdes ont les formules Image Image , où R est Image , Image , Image , Image , Image , Image , Image , Image , Image , Image , Image , Image , Image , Image et Image , où X est -H, -F, -Cl, -Br, -I, -OH, -OR, -OR', Image , Image , Image , -CN, -NO2, -NH2, -NHR' ou -NR'2; n est un nombre de 1 à 5; R' est H ou tout autre des alkyles inférieurs allant de C1 à C6; R" est Image , -OR', Image ou -R'; chaque R~ est R' ou le squelette hydrocarboné d'acides gras; lorsqu'il y a deux ou plusieurs groupes R', R" ou R~ , liés au même carbone ou azote, chaque groupe R', R" ou R~ peut être le même ou différent de l'autre groupe R', R", or R~ lié à ce carbone ou à cet azote.

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