Dermatan sulphate possessing a thrombolytic activity, and...

Details Dermatan sulphate possessing a thrombolytic activity, and... Dermatan sulphate possessing a thrombolytic activity, and...

C - Chemistry, Metallurgy

08

B

C08B 37/10 (2006.01) A61K 31/715 (2006.01) A61P 7/02 (2006.01) C08B 37/00 (2006.01) C12S 3/02 (2006.01) A61K 31/725 (1990.01)

Patent

CA 2116437

2116437 9305074 PCTABS00020 A natural dermatan sulphate with antithrombinic activity in excess of 220 U/mg, characterised by an oligosaccharide sequence with a high degree of sulphation, having formula (III) in which: n = integers 1 or 2; R4 = SO3-, or H; R6 = H, or SO3; G = glucuronic acid; I - non-sulphated uronic acid, preferably glucuronic acid, is extracted from organs, and subsequently purified in mild operating conditions, at pH 5-7 or in any case below 7, isolation and fractionation being carried out with macroreticular ion exchange resins having a particle size of 0.3-1.3 mm, and even less than 10 µ.

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