A - Human Necessities – 61 – P
Patent
A - Human Necessities
61
P
A61P 17/00 (2006.01) A61K 8/44 (2006.01) A61K 31/19 (2006.01) A61K 47/00 (2006.01) A61Q 19/00 (2006.01)
Patent
CA 2446926
A composition comprising at least one thyroid hormone compound or thyroid hormone-like compound, a hydrophilic phase-forming component, an amino alcohol and at least two emulsifying or emollient excipients selected from the group consisting of mineral oil, C~12-C~24 alcohols, C~12-C~24 carboxylic acids, C~1- C~8 branched or linear alkyl esters of C~12-C~24 carboxylic acids, glyceryl esters of C~12-C~24 carboxylic acids, macrogol ethers, polyethylene glycol esters of C~12-C~24 carboxylic acids, sorbitan esters of C~12-C~24 carboxylic acids (Span compounds) and polyoxyethylenated sorbitan esters of C~12-C~24 carboxylic acids (Tween compounds). A preferred thyroid hormone or thyroid hormone-like compound is triiodothyroacetic acid (TriAc; 4-(4-hydroxy-3- iodophenoxy-3,5-diiodophenyl)acetic acid) and a preferred amino alcohol is triethanolamine.
L'invention concerne une composition renfermant au moins un compos~ d'hormone thyro~de ou un compos~ de type hormone thyro~de, un composant de formation de phase hydrophile, un amino-alcool et au moins deux excipients ~mulsifiants ou ~mollients s~lectionn~s dans le groupe comprenant de l'huile min~rale, des alcools en C´12?-C´24?, des acides carboxyliques en C´12?-C´24?, des esters d'alkyle ramifi~s ou lin~aires en C´1?-C´8? d'acides carboxyliques en C´12?-C´24?, des esters de glyc~rol d'acides carboxyliques en C´12?-C´24?, des ~thers de macrogol, des esters de glycol poly~thylne d'acides carboxyliques en C´12?-C´24?, des esters d'arlitane d'acides carboxyliques en C´12?-C´24? (compos~s Span) et des esters d'arlitane polyoxy~thyl~n~s d'acides carboxyliques en C´12?-C´24? (compos~s Tween). Une hormone thyro~de ou un compos~ de type hormone thyro~de pr~f~r~ est un acide triiodothyroac~tique (TriAc; acide ac~tique 4-(4-hydroxy-3-iodoph~noxy-3,5-diiodoph~nyl)) et un amino-alcool pr~f~r~ est de la tri~thanolamine.
Hill & Schumacher
Karo Bio Ab
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