Des-c,d analogs of 1alpha,25-dihydroxy-19-norvitamin d3

Details Des-c,d analogs of 1alpha,25-dihydroxy-19-norvitamin d3 Des-c,d analogs of 1alpha,25-dihydroxy-19-norvitamin d3

C - Chemistry, Metallurgy

07

C

C07C 401/00 (2006.01) A61K 9/12 (2006.01) A61K 31/047 (2006.01) A61K 31/593 (2006.01)

Patent

CA 2620354

Des-C,D 2-methylene-19-norvitamin D3 analogs are provided including compounds of formula 1, in which R1 is a straight or branched chain alkyl or alkylene group having from 8 to 27 carbons and bearing an OY3 group; and Y1, Y2 and Y3 are independently selected from H or hydroxy-protecting groups. Such compounds may be used in preparing pharmaceutical compositions and are useful in treating a variety of biological conditions. Formula(I)

L'invention porte sur des analogues "des-c,d" d'1alpha,25-dihydroxy-19-norvitamine d3 consistant en composés de formule (I) dans laquelle: R1 est un groupe alkyle ou alkylène à chaîne droite ou ramifiée à 8 à 27 carbones et porteur d'un groupe OY3; et Y1, Y2 et Y3 sont sélectionnés indépendamment parmi H ou des groupes hydroxy-protecteurs. Lesdits composés peuvent servir à préparer des préparations pharmaceutiques et s'avèrent utiles pour traiter divers états biologiques.

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