Des-tyr dynorphin analogues

Details Des-tyr dynorphin analogues Des-tyr dynorphin analogues

C - Chemistry, Metallurgy

07

K

C07K 7/08 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) C07K 7/06 (2006.01) C07K 14/665 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2137916

Novel peptides of the invention are dynorphin analogues and have similar activity to endogenous dynorphin, but are des- Tyr or des-Tyr-Gly with respect to endogenous dynorphin. The novel peptides have therapeutic uses, such as administration to a host tolerant to a narcotic analgesic in order to potentiate activity of the narcotic analgesic and/or to block withdrawal symptoms.

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