Desacyl ghrelin antibodies and therapeutic uses thereof

Details Desacyl ghrelin antibodies and therapeutic uses thereof Desacyl ghrelin antibodies and therapeutic uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61P 3/04 (2006.01) A61P 3/06 (2006.01) A61P 3/10 (2006.01) C07K 14/575 (2006.01) C07K 16/26 (2006.01)

Patent

CA 2587627

A neutralizing epitope is identified within amino acids 1-3 of desacyl ghrelin. Antibodies that bind this epitope fall within the scope of the invention and can be murine, chimeric, or humanized antibodies, immunoconjugates of the antibodies, or antigen- binding fragments thereof. The antibodies of the invention are useful for the treatment or prevention of obesity and related disorders including, for example, Type II non-insulin dependent diabetes mellitus (NIDDM), Prader-Willi syndrome, eating disorders, hyperphagia, and impaired satiety. Additionally, such antibodies can be useful for the treatment or prevention of other disorders, including anxiety, gastric motility disorders (including e.g., irritable bowel syndrome and functional dyspepsia), insulin resistance syndrome, metabolic syndrome, dyslipidemia, atherosclerosis, hypertension, hyperandrogenism, polycystic ovarian syndrome, cancer, and cardiovascular disorders by administering a therapeutically effective amount of an anti-desacyl ghrelin monoclonal antibody of the invention.

L'invention concerne un épitope neutralisant identifié dans des acides amino 1-3 de désacyle ghréline. L'invention concerne également des anticorps qui se lient à cet épitope lesquels peuvent être murins, chimériques ou humanisés, des immunoconjugués d'anticorps ou des fragments de liaison à l'antigène de ces anticorps. Les anticorps de l'invention sont utiles dans le traitement ou la prévention de l'obésité et de ces troubles associés notamment, par exemple, le diabète non insulino-dépendant (DNID), le syndrome Prader-Willi, des troubles de l'alimentation, l'hyperphagie, et la diminution de la satiété. En outre, ces anticorps peuvent être utiles dans le traitement ou la prévention d'autres troubles, notamment l'anxiété, les troubles de la motilité gastrique (notamment, le syndrome du côlon irritable et la dyspepsie fonctionnelle), le syndrome de résistance à l'insuline, le syndrome métabolique, la dyslipidémie, l'athérosclérose, l'hypertension, l'hyperandrogénie, le syndrome des ovaires polycystiques, le cancer et les troubles cardio-vasculaires par administration d'une quantité efficace sur le plan thérapeutique d'un anticorps monoclonal anti-désacyle ghréline de l'invention.

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