Desaturase genes and uses thereof

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/53 (2006.01) A01H 5/00 (2006.01) A61K 31/20 (2006.01) A61P 3/00 (2006.01) C12N 9/02 (2006.01) C12N 15/09 (2006.01) C12N 15/63 (2006.01) C12N 15/82 (2006.01) C12P 7/64 (2006.01)

Patent

CA 2435685

The subject invention relates to the identification of genes involved in the desaturation of polyunsaturated fatty acids at carbon 5 (i.e., ".DELTA.5- desaturase") and at carbon 6 (i.e., ".DELTA.6-desaturase") and to uses thereof. In particular, .DELTA.5-desaturase may be utilized, for example, in the conversion of dihomo-g-linolenic acid (DGLA) to arachidonic acid (AA) and in the conversion of 20: 4n-3 to eicosapentaenoic acid (EPA). Delta-6 desaturase may be used, for example, in the conversion of linoleic (LA) to g- linolenic acid (GLA). AA or polyunsaturated fatty acids produced therefrom may be added to pharmaceutical compositions, nutritional compositions, animal feeds, as well as other products such as cosmetics.

La présente invention concerne l'identification de gènes impliqués dans la désaturation d'acides gras polyinsaturés au niveau du carbone 5 (c'est-à-dire, la ".DELTA.5-désaturase") et au niveau du carbone 6 (c'est-à-dire, la ".DELTA.6-désaturase") et les utilisations de ces derniers. De manière plus particulière, la .DELTA.5-désaturase peut être utilisée, par exemple, dans la conversion d'acide dihomo-g-linolénique (DGLA) en acide arachidonique (AA) et dans la conversion de 20: 4n-3 en acide eïcosapentaénoïque (EPA). La Delta-6 désaturase peut être utilisée, par exemple, dans la conversion d'acide linoléique (LA) en acide g-linolénique (GLA). L'acide arachidonique (AA) ou les acides gras polyinsaturés produits à partir de cette dernière, peuvent être ajoutés dans des compositions pharmaceutiques, des compositions nutritionnelles, des aliments pour animaux, ainsi que dans d'autres produits tels que des produits cosmétiques.

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