A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/135 (2006.01) A61K 31/137 (2006.01)
Patent
CA 2230359
This invention provides a method of treating patients suffering from malaria whilst avoiding cardioarrhythmias, the improvement thereof comprising the administration of desbutylhalofantrine in place of halofantrine. Dosage of 500 mg every six hours for three doses on day one with repeat of that dosage on day 7 for a total dosage of 3000 mg is appropriate for most treatment purposes in adults. Desbutylhalofantrine may also be given at dosage of 50 to 1000 mg as a prophylactic measure. Dosage may be given daily or one day per week.
L'invention concerne un procédé servant à traiter des malades atteints du paludisme, tout en évitant l'arythmie cardiaque, qui consiste à administrer la desbutylhalofantrine au lieu de l'halofantrine. Une dose de 500 mg toutes les six heures le premier jour et le renouvellement de cette dose le septième jour pour obtenir une dose totale de 3000 mg conviennent à la plupart des traitements chez l'adulte. On peut également administrer la desbutylhalofantrine en une dose de 50 à 1000 mg à titre prophylactique. On peut administrer cette dose de façon quotidienne ou hebdomadaire.
Schuster Brian
Wesche David
Woosley Raymond
Department Of The Army Us Government
Georgetown University
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
The Government Of The United States As Represented By The Secretary Of The Army
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