Design and discovery of protein based tnf-.alpha. variants...

Details Design and discovery of protein based tnf-.alpha. variants... Design and discovery of protein based tnf-.alpha. variants...

C - Chemistry, Metallurgy

12

N

C12N 15/28 (2006.01) A61K 38/19 (2006.01) A61P 29/00 (2006.01) C07K 14/525 (2006.01)

Patent

CA 2401683

The invention relates to novel proteins with TNF-.alpha. antagonist activity and nucleic acids encoding these proteins. The invention further relates to the use of the novel proteins in the treatment of TNF-.alpha. related disorders, such as rheumatoid arthritis.

La présente invention concerne de nouvelles protéines avec une activité antagoniste du TNF-.alpha. et des acides nucléiques codant pour ces protéines. Cette invention concerne aussi l'utilisation de ces nouvelles protéines dans le traitement des pathologies liées au TNF-.alpha., telles que l'arthrite rhumatoïde.

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