Design and synthesis of novel antimicrobials

Details Design and synthesis of novel antimicrobials Design and synthesis of novel antimicrobials

C - Chemistry, Metallurgy

07

D

C07D 409/02 (2006.01) A61K 31/41 (2006.01) A61P 31/00 (2006.01) A61P 31/04 (2006.01) C07D 409/04 (2006.01) C12Q 1/00 (2006.01)

Patent

CA 2603534

The synthesis and activity of novel LpxA inhibitors is described, these inhibitors present antibacterial activity. The compounds were designed based on a receptor model developed using the crystal structure of LpxA and are arranged to have a favorable binding interaction at the active site of the enzyme. In particular, the compounds present the following formula (I) where V, W, X, Y and Z can be independently C, S, N or O and Pl, P2 and P3 are ligands to bind to the three points of the proposed pharmacophore model. They can be chosen from a variety of groups.

L'invention concerne la synthèse de nouveaux inhibiteurs de LpxA et leur activité. Ces composés sont conçus sur un modèle de récepteur développé à l'aide de la structure cristalline de LpxA, et sont agencés pour présenter une interaction de liaison favorable sur le site actif de cette enzyme.

Affiliated with

Also associated with

Rating

Design and synthesis of novel antimicrobials does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Design and synthesis of novel antimicrobials, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Design and synthesis of novel antimicrobials will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1987494