Design and synthesis of novel tubulin polymerization...

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 239/38 (2006.01) A61K 31/505 (2006.01) A61P 35/00 (2006.01) C07D 239/34 (2006.01)

Patent

CA 2639658

This invention provides a series of BPU analogues; their synthesis and evaluated biological activity. BPU sulfur analogues were found to possess up to 20 fold increased potency, when compared to compound 1, in various cancerous cell lines.

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