A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/425 (2006.01) C07D 277/34 (2006.01)
Patent
CA 2533417
This invention provides new chemical entities useful for treating a variety of clinical disorders including those that areinfluenced by the activity of peroxisome proliferator activated receptors (PPAR). The structures of the compounds and methods to design, make and use the compounds are provided. Compounds and methods for administering therapeutic compositions comprising the compounds in cases of the disease psoriasis are provided. An exemplary compound having the formula compound is 5~adamantan-2-yl-pentanoic acid {2-[4- (2,4-dioxo-thiazolidin-5-yl-methyl)-phenoxy]-ethyl}-methyl-amide is provided.
L'invention porte sur de nouvelles entités chimiques qui servent à traiter une variété de troubles cliniques dont ceux qui sont influencés par l'activité des récepteurs activés par l'agent de prolifération de péroxysome (PPAR). L'invention concerne les structures de ces composés, ainsi que des procédés de conception, de fabrication et d'utilisation de ces composés. Elle porte aussi sur des composés et des procédés d'administration de compositions thérapeutiques contenant les composés en cas de psoriasis. L'invention a aussi trait à un composés représentatif représenté par la formule 5-adamantan-2-yl-pentanoique acide {2-[4-(2,4-dioxo-thiazolidin-5-yl-methyl)-phenoxy]-ethyl}-methyl-amide.
Avery Mitchell A.
Pershadsingh Harrihar A.
Bethesda Pharmaceuticals Inc.
Sim & Mcburney
The University Of Mississippi
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