C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/64 (2006.01) A61K 38/04 (2006.01) A61K 47/48 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/81 (2006.01)
Patent
CA 2431853
The present invention relates to MMP regulators that comprise new synthetic peptides, that comprise amino acid sequences structurally similar to those of MMP binding region of TIMPs, coupled to zinc chelators. The invention also relates to methods for making these MMP regulators and their use for the treatment of chronic and acute wounds and for the treatment of angiogenesis- associated diseases.
La présente invention porte sur des régulateurs de métalloprotéinases matricielles qui comprennent de nouveaux peptides synthétiques, comportant des séquences amino-acides, similaires par leur structure à celles de la région de liaison des métalloprotéinases matricielles des inhibiteurs tissulaires des métalloprotéinases, ces nouveaux peptides étant couplés aux chélateurs de zinc. L'invention porte également sur des procédés de fabrication de ces régulateurs de métalloprotéinases matricielles et sur leur utilisation dans le traitement de lésions chroniques et aiguës et de maladies associées à l'angiogenèse.
Quirk Stephen
Tyrrell David John
Borden Ladner Gervais Llp
Kimberly-Clark Worldwide Inc.
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