Design, cloning and expression of humanized monoclonal...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/13 (2006.01) A61K 39/395 (2006.01) C07K 16/24 (2006.01) C07K 16/46 (2006.01) C12N 5/10 (2006.01) C12N 15/62 (2006.01) C12P 21/08 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2129445

2129445 9316184 PCTABS00025 A monoclonal antibody is provided which specifically binds to human interleukin-5. Also provided are a hybridoma which produces the monoclonal antibody; complementary DNAs which encode the heavy and light chain variable regions of the monoclonal antibody and CDRs therefrom; humanized monoclonal antibodies; and pharmaceutical compositions comprising the monoclonal antibody or anti-idiotypic antibodies directed against it, humanized monoclonal antibodies, binding fragments, binding compositions or single-chain binding proteins derived from the antibody and a physiologically acceptable carrier.

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