Design, construction and expression of chimeric proteins for...

Details Design, construction and expression of chimeric proteins for... Design, construction and expression of chimeric proteins for...

C - Chemistry, Metallurgy

12

N

C12N 15/49 (2006.01) A01K 67/04 (2006.01) A61K 39/21 (2006.01) A61K 39/385 (2006.01) C07K 1/14 (2006.01) C07K 14/155 (2006.01) C07K 17/02 (2006.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) C12N 15/10 (2006.01) C12N 15/62 (2006.01) C12N 15/86 (2006.01)

Patent

CA 2084136

ABSTRACT The chimeric proteins, and the vaccine compring the chimeric protein are disclosed. The preparation comprises linking gag of HIV to env to form the chimeric gene, inserting the obtained chimeric gene into the DNA of baculovirus, infecting the resulted recommbinant virus with the insect cells or insect, culturing it and purifying the obtained chimeric protein. The gag chimeric protein of HIV according to the present invention retains both antigenic and immunogenic properties.

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