C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/00 (2006.01) C07K 1/00 (2006.01) C07K 7/08 (2006.01) C07K 14/005 (2006.01) C07K 14/14 (2006.01) C07K 14/16 (2006.01) C07K 14/725 (2006.01) C07K 14/73 (2006.01) C07K 14/74 (2006.01) C07K 16/10 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2091258
2091258 9204914 PCTABS00011 The present invention relates to a method for producing peptides which have biological activity comprising: (i) identifying a region of a protein of interest which is homologous to a member of the immunoglobulin superfamily of molecules; (ii) synthesizing a peptide which comprises amino acid sequence found in the region of homology; and (iii) modifying the synthetic peptide such that it assumes a three-dimensional conformation which is biologically active. The invention is based, in part, on the discovery that a cyclic peptide comprising amino acid sequences of a CDR derived from an antibody directed toward a viral receptor molecule can be used to effectively inhibit the binding of virus to its receptor. The invention is also based in part on the discovery that a cylic peptide corresponding to a portion of human immunodeficiency virus (HIV) gp120 that is homologous to immunoglobulins may be used to generate an anti-HIV immune response.
Greene Mark I.
Kieber-Emmons Thomas
Weiner David
Williams Robert M.
Williams William
Colorado State University
Smart & Biggar
The Trustees Of The University Of Pennsylvania
The Wistar Institute Of Anatomy And Biology
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