Designed degradable cage coated with mineral layers for...

A - Human Necessities – 61 – L

Patent

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Details

A61L 27/56 (2006.01) A61F 2/44 (2006.01) A61L 27/18 (2006.01) A61L 27/30 (2006.01) A61L 27/32 (2006.01) A61L 27/54 (2006.01)

Patent

CA 2671335

A cage for facilitating fusion of bones, such as vertebrae, or fusion of adjacent bone surfaces is disclosed. In one form, the cage includes a plurality of spaced apart walls comprising a biodegradable polymeric material (e.g., polycaprolactone); an osteoconductive mineral coating (e.g., a calcium compound) on at least a portion of the walls; and a bioactive agent (e.g., a bone morphogenetic protein) associated with the polymeric material and/or the coating The bioactive agent is present in amount that induces ossification between the bones or adjacent bone surfaces. The cage may also include a fixation plate connected to at least one of the walls.

L'invention concerne une cage pour faciliter la fusion d'os, tels que des vertèbres, ou la fusion de surfaces osseuses adjacentes. Dans une forme, la cage comprend une pluralité de parois espacées comprenant un matériau polymère biodégradable (par exemple polycaprolactone) ; un revêtement minéral ostéoconducteur (par exemple un composé de calcium) sur au moins une partie des parois ; et un agent bioactif (par exemple une protéine morphogénétique osseuse) associé au matériau polymère et/ou au revêtement. L'agent bioactif est présent en une quantité qui induit une ossification entre les os ou les surfaces osseuses adjacentes. La cage peut également inclure une plaque de fixation raccordée à au moins l'une des parois.

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