Desmethylolanzapine compositions and methods

Details Desmethylolanzapine compositions and methods Desmethylolanzapine compositions and methods

A - Human Necessities

61

K

A61K 31/551 (2006.01) A61P 1/00 (2006.01) A61P 25/00 (2006.01) A61P 25/18 (2006.01) A61P 25/22 (2006.01) A61P 25/24 (2006.01) A61P 25/30 (2006.01) A61P 31/10 (2006.01)

Patent

CA 2351718

Methods and compositions are disclosed utilizing N-desmethylolanzapine for the treatment of psychosis in humans. N-desmethylolanzapine exhibits a lessened liability toward drug-drug interactions than olanzapine and a more predictable dosing regimen than olanzapine. N-desmethylolanzapine is also useful for the treatment of acute mania, mild anxiety states, anxiety disorders, schizophrenia, bipolar disorder, attention deficit hyperactivity disorder, autistic disorder, excessive aggression, substance abuse, depressive signs and symptoms, tic disorder, functional bowel disorder and fungal dermatitis.

L'invention concerne des méthodes et des compositions utilisant la N-desméthylolanzapine pour le traitement des psychoses chez les humains. La N-desméthylolanzapine est moins exposée aux interactions entre médicaments que l'olanzapine et elle présente un schéma posologique plus prévisible que l'olanzapine. La N-desméthylolanzapine est également utile pour le traitement de la manie aiguë, des états anxieux légers, des troubles anxieux, de la schizophrénie, de la maladie affective bipolaire, du trouble d'hyperactivité avec déficit de l'attention, du trouble autistique, de l'agressivité excessive, des abus de substances psychoactives, des signes et des symptômes dépressifs, des tics, des troubles intestinaux fonctionnels et de la mycose.

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