Desolvating solvates of atorvastatin hemi-calcium

Details Desolvating solvates of atorvastatin hemi-calcium Desolvating solvates of atorvastatin hemi-calcium

C - Chemistry, Metallurgy

07

D

C07D 207/34 (2006.01) A61K 31/40 (2006.01) A61P 3/06 (2006.01)

Patent

CA 2475123

The present invention provides processes for removing organic solvent from crystals of atorvastatin hemi-calcium containing organic solvent. In one process, the organic solvent is displaced by vapor diffusion of water in a vessel maintained at elevated humidity. In a second process, the organic solvent is removed by fluidized bed drying. The present invention further provides atorvastatin hemi-calcium containing 1 % or less organic solvent, which can be obtained from atorvastatin hemi-calcium that has been crystallized from an organic solvent-containing solution by practice of the processes of the invention.

La présente invention concerne des processus pour évacuer les solvants organiques des cristaux de demi-calcium d'atorvastatine contenant un solvant organique. Dans un processus, le solvant organique est déplacé par la diffusion de la vapeur d'eau dans une cuve maintenue à humidité élevée. Dans un autre processus, le solvant organique est évacué par séchage de lit fluidisé. La présente invention concerne aussi un demi-calcium d'atorvastatine qui a été cristallisé à partir d'une solution contenant un solvant organique en utilisant les processus de l'invention.

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