Desosamino derivatives of macrolides as immunosuppressants...

Details Desosamino derivatives of macrolides as immunosuppressants... Desosamino derivatives of macrolides as immunosuppressants...

C - Chemistry, Metallurgy

07

H

C07H 19/01 (2006.01) A61K 31/70 (2006.01) C07D 498/18 (2006.01) C07H 23/00 (2006.01)

Patent

CA 2131371

2131371 9318042 PCTABS00025 Macrolides of formula (I) and methods of treatment of resistance to transplantation, fungal infections and autoimmune diseases such as rheumatoid arthritis and psoriasis using said macrolides of formula (I), wherein n is 1 or 2; A and B are taken together and form =O or A and B are taken separately and are each H or A is OH and B is H; R1 is a desosamino group; R2 is OH or a desosaminyloxy group; and R3 is an alkyl or allyl group.

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