C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 273/00 (2006.01) A61K 31/395 (2006.01) C07D 413/10 (2006.01) C07D 413/14 (2006.01)
Patent
CA 2292698
The invention relates to novel desoxycyclodepsipeptides of formula (I) in which C=X1, C=X2, C=X3 and C=X4 independently of each other respectively represent one of the CO, CS or CH2 groups, with at least one of these groups representing CH2. The invention also relates to their mixtures and derivatives. Said compounds are produced from cyclodepsipeptides having 24 ring members formed by alternating .alpha.-amino carboxylic acids and .alpha.- hydroxy carboxylic acids by complete or partial chemoselective reduction of the carbonyl groups of the amide function into methylene groups, using suitable reduction methods. The desoxycyclodepsipeptides produced according to the invention have an anthelmintic effect.
L'invention concerne de nouveaux désoxycyclodepsipeptides de formule (I) dans laquelle C=X?1¿, C=X?2¿, C=X?3¿ et C=X?4¿ représentent indépendamment les uns des autres un des groupes CO, CS ou CH¿2?, l'un au moins de ces groupes représentant CH¿2?, ainsi que leurs mélanges et leurs dérivés. Ces composés sont produits à partir de cyclodepsipeptides ayant 24 chaînons cycliques formés en alternance par des acides .alpha.-aminocarboxyliques et des acides .alpha.-hydroxycarboxyliques, par réduction complète ou partiellement chimiosélective des groupes carbonyle de la fonction amide en groupes méthyle par des procédés de réduction appropriés. Les désoxycyclodepsipeptides selon l'invention sont utilisés comme anthelmintiques.
Dyker Hubert
Harder Achim
Mencke Norbert
Samson-Himmelstjerna Georg von
Scherkenbeck Jurgen
Aktiengesellschaft Bayer
Fetherstonhaugh & Co.
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