A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61P 35/00 (2006.01) C07K 16/28 (2006.01) C07K 16/30 (2006.01) C07K 16/32 (2006.01) C07K 16/46 (2006.01)
Patent
CA 2642606
The present invention describes the use of trifunctional bispecific antibodies for the preparation of a pharmaceutical composition for the prophylaxis and treatment of tumor diseases. It has been found that said trifunctional bispecific antibodies are binding to tumor-associated antigens selected from Her2/neu, CD20, EpCAM, G250, proteoglycans, GD3, GD2, MHC II, EGF-R and CEA, wherein said tumor-associated antigens are expressed on said tumor cell with a low to medium expression level only.
La présente invention concerne l'utilisation d'anticorps bispécifiques trifonctionnels pour préparer une composition pharmaceutique pour la prophylaxie et le traitement de maladies tumorales. On a déterminé que lesdits anticorps bispécifiques trifonctionnels se lient à des antigènes associés à des tumeurs, sélectionnés parmi Her2/neu, CD20, EpCAM, G250, protéoglycans, GD3, GD2, MHC II, EGF-R et CEA, lesdits antigènes associés à des tumeurs étant exprimés sur lesdites cellules tumorales à un niveau faible ou moyen d'expression uniquement.
Lindhofer Horst
Oyen Wiggs Green & Mutala Llp
Trion Pharma Gmbh
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