Detecting prions in a sample and prion preparation and...

Details Detecting prions in a sample and prion preparation and... Detecting prions in a sample and prion preparation and...

C - Chemistry, Metallurgy

07

K

C07K 14/47 (2006.01) A01K 67/027 (2006.01) A61K 49/00 (2006.01) C12N 15/85 (2006.01) C12Q 1/00 (2006.01) G01N 33/68 (2006.01) G01N 37/00 (2006.01)

Patent

CA 2227328

The invention includes an artificial PrP gene, a transgenic animal containing a Prp gene of a heterologous animal, and a hybrid non-human animal with an ablated endogenous prion protein gene. Also disclosed are methods of assaying for the presence of prion particles in a sample by inoculating the claimed transgenic animals and observing the inoculated animals for symptoms associated with prion diseases.

L'invention concerne un gène PrP artificiel, un animal transgénique contenant un gène PrP d'un animal hétérologue, ainsi qu'un animal hybride, non humain, présentant un gène de protéine de prion endogène ayant subi une ablation. L'invention concerne également des procédés de mise en évidence de particules de prions dans un échantillon, lesquels consistent à inoculer les animaux transgéniques revendiqués, puis à observer ces animaux inoculés afin de constater chez eux des symptômes associés aux maladies provoquées par le prion.

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