Detection and imaging of target tissue

A - Human Necessities – 61 – K

Patent

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A61K 49/00 (2006.01) A61K 9/107 (2006.01) A61K 49/18 (2006.01) A61K 51/00 (2006.01) A61K 47/48 (2006.01)

Patent

CA 2650574

Methods for high resolution imaging of a suspected target tissue are encompassed by the invention. Such methods include administering low resolution and high resolution contrast agents specific to targeted cells or tissues. The contrast agents are allowed to bind to the target cells or accumulate in a target tissue. A low resolution imaging technique is used to localize an accumulation of the low resolution contrast agent in a target tissue. A high resolution image of the target tissue is then obtained to localize an accumulation of the higher resolution contrast agent, allowing the generation of a higher resolution image than that obtained by the use of the low resolution contrast agent alone. These methods may utilize nanoparticles optionally in an emulsion as a contrast agent.

L'invention concerne des procédés d'imagerie haute résolution d'un tissu cible suspect. Ces procédés comprennent l'administration d'agents de contraste à basse résolution et haute résolution spécifiques aux cellules ou aux tissus ciblés. Les agents de contraste se lient aux cellules cibles ou s'accumulent dans un tissu cible. Une technique d'imagerie à basse résolution est utilisée pour localiser une accumulation de l'agent de contraste à basse résolution dans un tissu cible. Une image à haute résolution du tissu cible est ensuite obtenue pour localiser une accumulation de l'agent de contraste à résolution supérieure, ce qui permet de générer une image avec une résolution supérieure à celle obtenue en utilisant l'agent de contraste à basse résolution seul. Comme agent de contraste, ces procédés peuvent utiliser des nanoparticules, le cas échéant en émulsion.

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