Detection and quantification of neu related proteins in the...

C - Chemistry – Metallurgy – 12 – P

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167/37, 530/15.0

C12P 21/08 (2006.01) C07K 14/82 (2006.01) C07K 16/32 (2006.01) C12N 5/18 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01)

Patent

CA 2026250

The invention relates to a substantially purified p100 which is a human neu related protein having a molecular weight in the range from about 97,000 daltons to about 115,000 daltons which corresponds substantially to the extracellular domain of the human neu gene product, said protein being detectable in a biological fluid. In another embodiment this invention relates to assays for detecting this protein. Finally, this invention also concerns monoclonal antibodies which are capable of binding to p100.

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