Detection and treatment of breast, gynecological and...

C - Chemistry – Metallurgy – 07 – H

Patent

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C07H 21/04 (2006.01) A01N 43/04 (2006.01) A61K 31/70 (2006.01) A61K 39/42 (2006.01) A61K 51/10 (2006.01) C07K 16/10 (2006.01) C12Q 1/68 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2297727

The present invention provides novel DNA sequences and polypeptides, which are associated with breast, gynecological, and prostate carcinomas. The present invention also provides methods for detecting and treating breast, gynecological and prostate cancers. In a preferred embodiment, these methods utilize a monoclonal antibody developed against a synthetic peptide corresponding to a viral protein of the Human Immunodeficiency Virus (HIV-1). In a more preferred embodiment, the antibody is directed against the envelope protein gp120 (amino acid region 308-322). Regions of homology between HIV-1 and breast and gynecological cancer sequences are identified as are methods for diagnosis and treatment based on the conserved regions.

L'invention concerne de nouvelles séquences d'ADN et des poylpeptides qui sont associés aux cancers du sein, aux cancers gynécologiques et au cancer de la prostate. L'invention concerne également de techniques permettant de détecter et de traiter les cancers du sein, les cancers gynécologiques et les cancers de la prostate. Dans un mode de réalisation préféré, ces techniques comprennent l'utilisation d'un anticorps monoclonal développé contre un peptide synthétique correspondant à une protéine du virus de l'immunodéficience humaine (VIH-1). Dans un mode de réalisation encore préféré au précédent, l'anticorps est dirigé contre la protéine enveloppe gp120 (région d'acides aminés 308-322). Les régions d'homologie entre le VIH-1 et les séquences du cancer du sein et des cancers gynécologiques sont identifiés ainsi, que des méthodes de diagnostic et de traitement basées sur les régions conservées.

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