Detection of a target in a sample

Details Detection of a target in a sample Detection of a target in a sample

G - Physics

01

N

G01N 27/327 (2006.01) C12Q 1/68 (2006.01) C40B 30/00 (2006.01) C40B 60/12 (2006.01) G01N 27/416 (2006.01) G01N 33/53 (2006.01) G01N 33/543 (2006.01)

Patent

CA 2331688

The invention concerns a system, device, kit and method for detecting the presence, or concentration of a target in a sample. An assay set comprising at least two spaced apart electrodes is used, comprising a recognition moiety, capable of specific binding to the target, which is attached to at least one of the electrodes or the substrate therein between. If the recognition moiety binds the target then a conductive bridge can be formed between the electrodes, based on the complex between the recognition moiety and the target. The conductive bridge is formed by using nucleation-center forming entities attached to said complexes or to said targets from which a conductive substance is substantially grown. Alternatively the conducting bridge forms a conductive polymer between the electrodes.

L'invention concerne un système, un dispositif, un kit et un procédé pour la détection de la présence ou de la concentration d'une cible dans un échantillon. On utilise un ensemble d'essai comprenant au moins deux électrodes séparées, contenant un fragment de reconnaissance capable de se lier spécifiquement à la cible, fixé à au moins une des électrodes ou au substrat placé entre celles-ci. Si le fragment de reconnaissance se lie à la cible, un pont conducteur peut être alors formé entre les électrodes, basé sur le complexe produit par le fragment de reconnaissance et la cible. On forme le pont conducteur en utilisant des entités formant un centre de nucléation, fixées auxdits complexes ou auxdites cibles à partir desquelles une substance conductrice est sensiblement cultivée. Le pont conducteur peut également former un polymère conducteur entre les électrodes.

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