C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
167/40, 167/43
C07K 16/28 (2006.01) A61K 49/00 (2006.01) A61K 49/04 (2006.01) A61K 51/10 (2006.01)
Patent
CA 1264029
Abstract of the Disclosure A diagnostic site-specific imaging reagent in the form of a receptor and an indicating means selectively binds to a specific cell membrane-associated antigen of a blood platelet that is in a stimulated active state but does not substantially bind to a platelet that is in a non-stimulated resting state. In particular, prelabelled monoclonal antibodies and polyclonal antibodies are prepared that bind and image thrombospondin when it is cell membrane-associated on a thrombin-stimulated platelet, thereby providing means for detecting and discriminating between a stimulated active blood platelet and a non-stimulated resting blood platelet.
505740
Ginsberg Mark H.
Plow Edward F.
Fetherstonhaugh & Co.
Scripps Clinic And Research Foundation
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