G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/543 (2006.01) A61K 47/48 (2006.01) G01N 33/548 (2006.01) G01N 33/566 (2006.01) G01N 33/58 (2006.01)
Patent
CA 2045673
2045673 9008957 PCTABS00001 A method for detection for screening and diagnostic purposes of antibodies in a body fluid by means of an antibody-binding protein covalently bound to a porous matrix trapped within a transparent column. A test fluid containing antibody is contacted with the protein-bound matrix whereby the protein reacts with to immobilize any antibody present in the test fluid. A biotinylated antigen of interest is contacted with the immobilized antibody whereby the biotinylated antigen binds to the immobilized antibody. Avidin covalently linked to an enzyme is contacted with the immobilized biotinylated antigen-immobilized antibody-protein bound matrix complex whereby the enzyme-labelled avidin binds to the immobilized complex. This immobilized complex is contacted with a substrate solution wherein the enzyme linked to avidin catalyzes a reaction of the substrate and produces a detectable reaction product which correlates to the presence of the antibody to be detected.
Fellman Jack H.
Ferro Adolph
Gavojdea Stefan
Thieme Thomas R.
Epitope Inc.
Kirby Eades Gale Baker
LandOfFree
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