Detection of asymptomatic coronary artery disease using...

G - Physics – 01 – N

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G01N 33/53 (2006.01) G01N 33/577 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2553457

A method of assessing the likelihood that a person who is asymptomatic for coronary artery disease does in fact have the disease is disclosed. The levels of an atherogenic protein and acute phase reactant and optionally of anti- atherogenic protein for an individual are obtained and compared to one or more cut-points related to those substances and, based on the comparison(s), an assessment is made of the likelihood that the individual has coronary artery disease. The atherogenic protein may be OxLDL, the acute phase reactant may be C-reactive protein or fibrinogen, and the anti-atherogenic protein may be HDL.

La présente invention se rapporte à un procédé permettant d'évaluer la probabilité qu'une personne ne présentant aucun symptôme de la maladie coronarienne soit effectivement atteinte de la maladie. Le procédé consiste à obtenir les niveaux d'une protéine athérogène et d'un réactif de phase aiguë, et éventuellement d'une protéine anti-athérogène, présentés par une personne, à les comparer à un ou plusieurs points de découpage liées à ces substances, et, sur la base de la ou les comparaisons, à évaluer la probabilité que ladite personne soit atteinte de la maladie coronarienne. La protéine athérogène peut être OxLDL, le réactif de phase aiguë peut être une protéine C-réactive ou un fibrinogène, et la protéine anti-athérogène peut être HDL.

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