Detection of biological molecules using chemical...

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G01N 33/48 (2006.01) A61B 5/00 (2006.01) C12Q 1/00 (2006.01) C12Q 1/26 (2006.01) C12Q 1/28 (2006.01) C12Q 1/54 (2006.01)

Patent

CA 2235738

Methods are provided for the determination of the concentration of biological levels of polyhydroxylated compounds, particularly glucose. The methods utilize an amplification system that is an analyte transducer immobilized in a polymeric matrix, where the system is implantable and biocompatible. Upon interrogation by an optical system, the amplification system produces a signal capable of detection external to the skin of the patient. Quantitation of the analyte of interest is achieved by measurement of the emitted signal.

L'invention se rapporte à des procédés visant à déterminer les taux biologiques de composés polyhydroxylés, notamment le glucose. Ces procédés font appel à un système d'amplification qui est un transducteur d'analytes immobilisés dans une matrice polymère, le système étant implantable et biocompatible. Lors d'une interrogation effectuée par un système optique, le système d'amplification génère un signal capable de réaliser une détection à l'extérieur de l'épiderme du patient. On parvient à quantifier l'analyte en question en mesurant le signal émis.

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