Detection of cancer by assaying for cancer-specific antigens...

Details Detection of cancer by assaying for cancer-specific antigens... Detection of cancer by assaying for cancer-specific antigens...

G - Physics

01

N

G01N 33/574 (2006.01) G01N 33/573 (2006.01)

Patent

CA 2259501

A process for assaying for cancer of the prostate, comprising assaying a sample derived from a human for prostate specific antigen having a linked oligosaccharide which is at least triantennary. The assay may employ a binding molecule which binds to oligosaccharides that are at least triantennary, but does not bind to oligosaccharides that are monoantennary or diantennary. Such binding molecule may be a lectin such as PHA-L or an antibody to an oligosaccharide that is at least triantennary.

L'invention concerne un procédé de dépistage par analyse du cancer de la prostate, consistant à analyser un échantillon prélevé chez un homme pour y rechercher un antigène spécifique de la prostate possédant un oligosaccharide lié qui est au moins triantennaire. Pour réaliser l'analyse, on peut utiliser une molécule de fixation qui se fixe aux oligosaccharides qui sont au moins triantennaires, mais qui ne se fixent pas aux oligosaccharides qui sont monoantennaires ou biantennaires. De telles molécules de fixation peuvent être la léctine telle que PHA-L ou un anticorps dirigé contre un oligosaccharide qui est au moins triantennaire.

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