C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) G01N 33/58 (2006.01)
Patent
CA 2492048
Novel compounds having a fluorescence quencher as a leaving group are disclosed. Nucleic acids and other molecules containing a fluorophore and a fluorescence quencher are disclosed as an embodiment of this invention. The use of the oligonucleotides in enzyme-free oligonucleotide ligation reactions results in an increase in fluorescence when the oligonucleotide also contains a nearby fluorophore. The ligation reactions can be performed in solution, on surfaces, or in cells.
Cette invention se rapporte à de nouveaux composés comportant un agent d'extinction de fluorescence comme groupe partant. Des acides nucléiques et d'autres molécules contenant un fluorophore et un agent d'extinction de fluorescence sont décrits comme mode de réalisation de cette invention. L'utilisation des oligonucléotides dans des réactions de ligature d'oligonucléotides sans enzyme entraîne une augmentation de la fluorescence, lorsque l'oligonucléotide contient également un fluorophore voisin. Les réactions de ligature peuvent être effectuées en solution, sur des surfaces ou dans des cellules.
Gowling Lafleur Henderson Llp
The Board Of Trustees Of The Leland Stanford Junior University
LandOfFree
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