Detection of cyp1a1, cyp3a4, cyp2d6 and nat2 variants and...

Details Detection of cyp1a1, cyp3a4, cyp2d6 and nat2 variants and... Detection of cyp1a1, cyp3a4, cyp2d6 and nat2 variants and...

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01)

Patent

CA 2346125

The present invention relates to the detection of genetic polymorphisms in gene encoding xenobiotics metabolizing enzymes CYP1A1, CYP2D6, CYP3A4, and NAT2. In particular, the present invention relates to a method of detecting genetic variation in individuals by amplifying the locus of interest, hybridizing the resulting amplification product with allele-specific- oligonucleotides (ASOs), and visualizing the results. Such a method is in the field of diagnostics, pharmacogenetics, therapeutics, and drug metabolism.

Cette invention se rapporte à la détection des polymorphismes génétiques dans des gènes codant les enzymes CYP1A1, CYP2D6, CYP3A4 et NAT2 qui ont une action métabolisant les xénobiotiques. Cette invention se rapporte particulièrement à un procédé servant à détecter des variations génétiques chez des individus, en amplifiant le locus concerné, en hybridant le produit d'amplification qui en résulte avec des oligonucléotides spécifiques à l'allèle (ASO) et en visualisant les résultats obtenus. Un tel procédé s'applique dans le domaine du diagnostic, de la pharmacogénétique, de la thérapeutique et du métabolisme des médicaments.

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