Detection of esr1 amplification in endometrium cancer and...

C - Chemistry – Metallurgy – 12 – Q

Patent

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C12Q 1/68 (2006.01)

Patent

CA 2683509

The present invention relates to an in-vitro method of identifying a tumor resulting from a proliferative disease of the endometrium or ovary as responsive to anti-estrogen treatment. Further, the invention relates to an in-vitro method of identifying a candidate patient with a proliferative disease of the endometrium or ovary as suitable for anti-estrogen treatment. In a further aspect, the invention provides an in-vitro method of identifying an individual with a non-cancerous proliferative disease of the endometrium or ovary who is at risk of developing endometrial or ovarian cancer. The invention also provides kits for performing the above methods.

L'invention concerne un procédé in vitro qui permet d'identifier une tumeur causée par une maladie proliférative de l'endomètre ou de l'ovaire en réponse à un traitement par anti-oestrogènes. L'invention se rapporte en outre à un procédé in vitro qui permet d'identifier une patiente candidate atteinte d'une maladie proliférative de l'endomètre ou de l'ovaire comme étant apte à un traitement par anti-oestrogènes. Dans un autre aspect, l'invention porte sur un procédé in vitro permettant d'identifier un individu atteint d'une maladie proliférative non cancéreuse de l'endomètre ou de l'ovaire, qui court le risque de développer un cancer de l'endomètre ou de l'ovaire. L'invention concerne aussi des trousses destinées à la mise en oeuvre des procédés précités.

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