C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01)
Patent
CA 2393669
This invention relates to detection of specific extracellular nucleic acid in plasma or serum fractions of human or animal blood associated with neoplastic, pre-malignant or proliferative disease. Specifically, the invention relates to detection of nucleic acid derived from mutant oncogenes or other tumor- associated DNA, and to those methods of detecting and monitoring extracellular mutant oncogenes or tumor-associated DNA found in the plasma or serum fraction of blood by using DNA extraction with or without enrichment for mutant DNA.
L'invention porte sur la détection d'acide nucléique extracellulaire spécifique dans des fractions du plasma ou du sérum du sang humain ou animal associé à des maladies néoplasiques, pré-malignes ou prolifératives. L'invention porte plus spécifiquement sur la détection d'acide nucléique dérivant d'oncogènes mutants ou d'autres ADN associés à des tumeurs, ainsi que sur des méthodes de détection et de contrôle d'oncogènes mutants extracellulaires ou des AND associés aux tumeurs présents dans les fractions du plasma ou du sérum du sang par extraction de l'ADN, avec ou sans enrichissement pour l'ADN mutant.
Gocke Christopher D.
Kopreski Michael S.
Mbm Intellectual Property Law Llp
The Penn State Research Foundation
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