Detection of high grade dysplasia in cervical cells

Details Detection of high grade dysplasia in cervical cells Detection of high grade dysplasia in cervical cells

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01)

Patent

CA 2501792

Methods of using probes and probe sets for the detection of high-grade dysplasia and carcinoma in cervical cells are described. Methods of the invention include hybridizing one or more chromosomal probes to a biological sample obtained from a subject and detecting the hybridization pattern of the chromosomal probes to the sample to determine whether the subject has high grade dysplasia or carcinoma. Methods of the invention also include preliminary screening the cells for a marker associated with a risk for cancer, and preferably involves screening for HPV infected cells by in situ hybridization using an HPV probe mixture.

Cette invention se rapporte à des procédés utilisant des sondes et des jeux de sondes pour détecter la dysplasie de haut degré et le carcinome dans des cellules cervicales. Ces procédés consistent à hybrider une ou plusieurs sondes chromosomiques sur un échantillon biologique obtenu à partir d'un sujet, et à détecter la structure d'hybridation des sondes chromosomiques sur l'échantillon, afin de déterminer si le sujet souffre d'une dysplasie de haut degré ou d'un carcinome. Ces procédés consistent également à cribler préalablement les cellules pour détecter un marqueur associé à un risque de cancer, et ils impliquent de préférence un criblage servant à détecter les cellules infectées par HPV par hybridation in situ au moyen d'un mélange de sondes de HPV.

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