Detection of human papillomavirus

Details Detection of human papillomavirus Detection of human papillomavirus

C - Chemistry, Metallurgy

12

Q

C12Q 1/70 (2006.01)

Patent

CA 2557519

The present invention relates to in vitro methods of screening human subjects for the presence of human papillomavirus (HPV) which exhibits loss of regulation of E6/E7 mRNA expression and loss of replication and/or expression of a stabilized pre-mRNA encoding full length E6 protein. In particular, the invention provides in vitro methods of screening for persistent cell abnormalities or persistent CIN III lesions, cancer in situ or high-grade squamous intraepithelial lesions (HSIL). The methods are useful in the context of cervical cancer screening.

La présente invention porte sur des méthodes in vitro visant à détecter chez des patients la présence du papillomavirus humain (HPV) qui présente une perte de régulation de l'expression de l'ARNm E6/E7 et une perte de réplication et/ou de l'expression d'une protéine E6 pleine longueur codant un pré-ARNm stabilisé. L'invention porte notamment sur des méthodes in vitro visant à dépister des anomalies cellulaires persistantes ou des lésions persistantes CIN III, un cancer in situ ou des lésions intra-épithéliales malpighiennes de haut grade de malignité (HSIL). Ces méthodes sont utiles dans le dépistage du cancer du col utérin.

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