Detection of hypoxia

Details Detection of hypoxia Detection of hypoxia

C - Chemistry, Metallurgy

07

D

C07D 233/91 (2006.01) A61K 31/415 (2006.01) A61K 39/385 (2006.01) A61K 49/00 (2006.01) A61K 51/10 (2006.01) C07K 14/76 (2006.01) C07K 14/81 (2006.01) C12N 9/36 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01) C07K 16/44 (2006.01)

Patent

CA 2149770

Novel nitroaromatic compounds and immunogenic conjugates comprising a novel nitroaromatic compound and a carrier protein are disclosed. The invention further presents monoclonal antibodies highly specific for the claimed nitroaromatic compounds, the compounds' protein conjugates, the compounds' reductive by- products, and adducts formed between the compounds and mammalian hypoxic cell tissue proteins. The invention is further directed to methods for detecting tissue hypoxia using immunohistological techniques, non-invasive nuclear medicinal methods, or nuclear magnetic resonance. Diagnostic kits useful in practicing the methods of claimed invention are also provided.

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