Detection of immunological memory, t-cell conjugates for...

C - Chemistry – Metallurgy – 12 – N

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C12N 5/0783 (2010.01) A61K 39/00 (2006.01) A61K 41/00 (2006.01) A61K 51/12 (2006.01) A61P 35/00 (2006.01) G01N 33/569 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2403760

A method for detecting prior exposure of an individual mammal's immune system to an antigen associated with a pathological process comprises exposing T- cells to a complex antigen mixture, and detecting a pre-existing T-cell specificity for an unknown antigen in said complex antigen mixture. Labelled T- cells are then used to image the site of the pathology and T-cells conjugated to a cytotoxic agent or precursor are used to treat the pathology.

La présente invention concerne un procédé de détection avant exposition du système immunitaire d'un mammifère à un antigène associé à un processus pathologique, consistant à exposer les cellules T à un mélange d'antigènes complexe, et à détecter la spécificité des cellules T préexistantes vis-à-vis d'un antigène non découvert dans ledit mélange d'antigènes complexe. Les cellules T marquées sont ensuite utilisées pour représenter en images le site malade, les cellules T conjuguées à un agent cytotoxique ou un précurseur étant utilisées pour traiter la maladie.

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