Detection of infectious agents using antigen mimics

Details Detection of infectious agents using antigen mimics Detection of infectious agents using antigen mimics

G - Physics

01

N

G01N 33/576 (2006.01) C07K 7/08 (2006.01) C07K 14/18 (2006.01) C12N 15/10 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2427602

A method for making a diagnosis of an antigen, comprising identifying the binding specificity of the anti-antigen antibody molecules in the serum by the Antibody Detection by Antigen Mimics (ADAM) methodology, comprising screening phage libraries using sera from antigen-infected patients and non-infected individuals, identifying peptides binding antibodies (ligands) specifically associated with said antigen. Improvements of the method are given by in vitro maturation strategies; linking the ligands to a common core, such as MAP. In particular the method applies to HCV.

L'invention concerne un procédé permettant d'effectuer le diagnostic d'un antigène. Ce procédé consiste à identifier la spécificité de liaison des molécules de l'anticorps anti-antigène dans le sérum au moyen de la méthode ADAM (détection d'un anticorps par mimiques d'antigènes). Ce procédé consiste à cribler des bibliothèques de phages au moyen de sérums tirés de patients infectés par des antigènes et des sujets non infectés et à identifier des anticorps se liant aux peptides (ligands) associés de manières spécifique audit antigène. Pour améliorer ledit procédé, on utilise des stratégies de maturation in vitro, on lie les ligands à un noyau commun, tel que MAP. Ledit procédé s'applique notamment au virus de l'hépatite C.

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