Detection of isomerised epitopes in autoimmune diseases

Details Detection of isomerised epitopes in autoimmune diseases Detection of isomerised epitopes in autoimmune diseases

G - Physics

01

N

G01N 33/564 (2006.01) C07K 14/47 (2006.01)

Patent

CA 2382205

Antibodies and T-lymphocytes having immune reactivity with proteins isomerised at an aspartic acid, asparagine, glutamine or glutamic acid residue are found to be associated with auto-immune conditions involving auto-reactivity to IgG (rheumatoid arthritis) and myelin basic protein (multiple sclerosis). Diagnosis assays for auto-immune reactivity to isomerised protein sequences are described.

Selon l'invention, on a découvert que des anticorps et des lymphocytes T présentant une réactivité immunitaire contre des protéines isomérisées au niveau d'un résidu d'acide aspartique, d'asparagine, de glutamine ou d'acide glutamique sont associés à des maladies auto-immunes impliquant une auto-reactivité contre IgG (polyarthrite rhumatoïde) ou contre la protéine basique de la myéline (sclérose en plaques). L'invention concerne également des essais diagnostiques destinés à déterminer la réactivité auto-immune contre des séquences de protéines isomérisées.

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