Detection of lethality gene for improved fertility in mammals

C - Chemistry – Metallurgy – 07 – H

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C07H 21/00 (2006.01) A01K 67/02 (2006.01) C07H 21/04 (2006.01) C12N 15/12 (2006.01) C12Q 1/68 (2006.01) C40B 40/06 (2006.01)

Patent

CA 2645861

Oligonucleic acid molecules comprising a SNP site at a position corresponding to position 7480 of the bovine signal transducer and activator of transcription (STAT5A) coding sequence (SEQ ID NO: 1). Also disclosed are an array or a kit comprising the same, a method for detecting the SNPs, a method for progeny testing of mammals, a method for increasing human and non-human mammal pregnancy rate in natural and artificial reproduction processes. Further provided are cattle breeding methods for improved milk production traits.

L'invention concerne des molécules d'acides oligonucléiques comprenant un site de polymorphisme d'un seul nucléotide (SNP) à une position correspondant à la position 7480 de la séquence de codage (SEQ ID NO: 1) de la protéine activatrice et transductrice de la transcription du signal bovin (STAT5A). Cette invention a aussi pour objet un jeu ou un kit contenant lesdites molécules, une méthode visant à détecter des SNP, une méthode conçue pour tester la descendance de mammaliens, une méthode destinée à augmenter le taux de grossesses humaines et non humaines dans des processus de reproduction naturels et artificiels. Ladite invention a également trait à des méthodes de reproduction de bovins en vue d'obtenir de meilleures caractéristiques du processus de production de lait.

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