Detection of mutations

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/53 (2006.01) C12N 9/02 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2472801

The present invention relates to a polypeptide which is a flavin-containing monooxygenase 3 (FMO3), wherein said FMO3 is a polypeptide comprising at least a sequence having at least 85% identity with the polypeptide sequence SEQ ID NO: 15, in particular to a polypeptide which is a functionally altered mutant of flavin-containing mono oxygenase 3 (FMO3) leading to a buildup of trimethylamine in an animal. Further, the invention relates to nucleic acid sequences encoding said polypeptide, and to the complements of such nucleic acid sequences. Such nucleic acid sequences and fragments thereof may be useful e.g. as primers. The invention further relates to various methods for determining the presence in e.g. a nucleic acid sample of a nucleic acid sequence encoding a mutated FMO3 polypeptide.

L'invention concerne un polypeptide qui est une mono-oxygénase 3 contenant de la flavine(FMO3). FMO3 est un polypeptide comprenant au moins une séquence qui présente au moins 85 % d'identité avec la séquence polypeptidique SEQ ID NO: 15 ; en particulier un polypeptide qui est un mutant fonctionnellement modifié d'une mono-oxygénase 3 contenant de la flavine (FMO3) et induit une accumulation de triméthylamine chez un animal. De plus, l'invention a trait à des séquences d'acide nucléique codant pour ledit polypeptide, et à des compléments de ces séquences. Lesdites séquences d'acide nucléique et leurs fragments peuvent être utiles, p. ex. comme amorces. L'invention se réfère aussi à divers procédés visant à déterminer la présence, dans un échantillon d'acide nucléique par exemple, d'une séquence d'acide nucléique codant pour un polypeptide FMO3 mutant.

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