C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) A61K 31/7088 (2006.01) C07K 16/40 (2006.01) C12N 15/11 (2006.01) C12N 15/54 (2006.01)
Patent
CA 2543789
A method for detecting a mutation related to the gene encoding OAS 1. This and other disclosed mutations correlate with resistance of humans to viral infection including hepatitis C. Also provided is a therapeutic agent consisting of a protein or polypeptide encoded by the mutated gene, or a polynucleotide encoding the protein or polypeptide. Inhibitors of human OAS 1, including antisense oligonucleotides, methods, and compositions specific for human OASI, are also provided.
L'invention concerne un procédé de détection d'une mutation se rapportant au codage du gène OAS1. Cette mutation et d'autres encore selon l'invention sont mises en corrélation avec la résistance des humains à des infections virales dont l'hépatite C. Elle concerne également un agent thérapeutique constitué d'une protéine ou d'un polypeptide codé par le gène mutant, ou d'un polynucléotide codant la protéine ou le polypeptide. L'invention concerne enfin des inhibiteurs de l'OAS1 humain, y compris des oligonucléotides antisens, ainsi que des procédés et des compositions spécifiques à l'OAS1 humain.
Guillaudeux Thierry
Iadonato Shawn P.
Magness Charles L.
Rosenberg Gary
Scherer Christina A.
Gowling Lafleur Henderson Llp
Illumigen Biosciences Inc.
Kineta Two Llc
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