C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
167/139, 167/37,
C12N 15/12 (2006.01) C07K 14/71 (2006.01) C07K 16/18 (2006.01) C07K 16/32 (2006.01) C12P 21/08 (2006.01) C12Q 1/68 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01) A61K 38/00 (2006.01)
Patent
CA 1341191
Nucleic acid probes reactive with regions of neu proto-oncogenes and/or oncogenes of mammalian origin are described, as are methods for their use in detecting the presence of neu proto-oncogenes and/or oncogenes in tumor cells. Antibodies specific for gene products encoded by the neu genes are also described. The nucleic acid probes and antibodies can be used to assess point mutational activation, amplification and overexpression of the neu genes and thus are useful in the diagnosis and prognosis of certain cancers.
597017
Marks Paula J.
Mazzara Gail Patricia
Mckenzie Sara Jane
Morgan Jonathan H.
Weinberg Robert Allan
Marks Paula J.
Mazzara Gail Patricia
Mckenzie Sara Jane
Morgan Jonathan H.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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