Detection of neurodegenerative disorders

Details Detection of neurodegenerative disorders Detection of neurodegenerative disorders

G - Physics

01

N

G01N 33/53 (2006.01) A61K 31/423 (2006.01) A61P 25/16 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2425187

The present invention relates to methods of detecting neurodegenerative diseases or disorders, particularly to methods for early detection of neurodegenerative diseases, such as Parkinson's disease. The present invention provides a method for detecting a neurodegenerative disease in a subject, the method comprising testing the subject for an indicator of release of neuromelanin from cells in the brain, wherein a positive test is indicative of death of brain cells containing neuromelanin and is characterised by an elevated level of the indicator of release of neuromelanin compared to control values.

L'invention concerne des méthodes permettant de détecter des maladies ou des troubles neurodégénératifs, en particulier des méthodes de détection précoce d'affections neurodégénératives, telles que la maladie de Parkinson. L'invention concerne une méthode de détection d'une affection neurodégénérative chez un sujet, qui consiste à vérifier si le sujet présente un indicateur de libération de neuromélanine provenant de cellules du cerveau. Un résultat positif indique la mort de cellules cérébrales contenant de la neuromélanine et se caractérise par un taux élevé d'indicateur de libération de neuromélanine comparativement à des valeurs de contrôle.

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