Detection of pleiotrophin

Details Detection of pleiotrophin Detection of pleiotrophin

G - Physics

01

N

G01N 33/574 (2006.01) G01N 33/577 (2006.01)

Patent

CA 2346406

The invention relates to a novel method and kit for detecting and measuring pleiotrophin in samples and diagnosing pleiotrophin-positive diseases. The method involves incubating a sample suspected of containing PTN with anti--PTN antibodies and determining the presence of PTN using a sandwich ELISA. Also methods for treating a pleiotrophin-positive disease by administering an anti--PTN antibody or fragment thereof are provided.

L'invention concerne un nouveau procédé et une trousse pour détecter et mesurer la pléiotrophine dans des prélèvements, et pour diagnostiquer des maladies liées à la pléiotrophine. Le procédé consiste à incuber un prélèvement présumé contenir la PTN au moyen d'anticorps anti-PTN, et à déterminer la présence de la PTN par une technique en sandwich ELISA. L'invention concerne en outre des procédés de traitement d'une maladie liée à la pléiotrophine par administration d'un anticorps anti-PTN ou d'un fragment dudit anticorps.

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