G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/68 (2006.01)
Patent
CA 2526898
The invention relates to methods for detecting infectious or pathogenic prion protein with improved sensitivity. According to the invention, a protease- resistant prion protein PrPSc is freshly formed by a spontaneous transformation reaction by means of interaction of non-pathogenic prion protein PrPc in the sample with low-molecular protease-sensitive PrPSc aggregates, in order to form high-molecular protease-resistant PrPSc aggregates.
L'invention concerne un procédé de détection, à sensibilité accrue, de prion-protéine infectieuse ou pathogène. A cet effet, on effectue une formation de novo une prion-protéine résistant à la protéase PrPSc, par réaction de transformation spontanée par interaction de prion-protéine non-pathogène PrPc dans l'échantillon, avec des agrégats de PrPSc faiblement moléculaires, sensibles à la protéase, en vue de former des agrégats de PrPSc hautement moléculaires, résistant à la protéase.
Gassner Dieter
Golla Ruth
Borden Ladner Gervais Llp
F. Hoffmann-La Roche Ag
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