C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/70 (2006.01) C07K 14/15 (2006.01) C07K 16/10 (2006.01) G01N 33/569 (2006.01)
Patent
CA 2289939
The present invention is based upon the finding that porcine endogenous retroviruses exist in two different subtypes, which we have termed PERV-A and PERV-B. The differences are reflected in sequence divergence in the envelope genes, and these differences may be used to provide nucleic acid and antibody probes which can distinguish between the two subtypes. This allows patterns of subtype transmission between cells, particularly porcine to human cells, to be monitored.
La présente invention est fondée sur la découverte selon laquelle des rétrovirus endogènes porcins présentent deux sous-types différents, que nous avons dénommés PERV-A et PERV-B. Ces différences se traduisent par une différence de séquences dans les gènes d'enveloppe, et peuvent être exploitées pour produire des sondes d'acide nucléique ou d'anticorps permettant de déterminer les deux sous-types. On peut ainsi surveiller les modes de transmission de sous-types entre cellules, notamment de la cellule porcine à la cellule humaine.
Stoye Jonathan Paul
Weiss Robin Anthony
Borden Ladner Gervais Llp
Medical Research Council
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